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Cancer: Lymphoma

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Total 26407 results found since Jan 2013.

Extra-vascular findings in patients undergoing magnetic resonance angiography of the abdomen, pelvis and lower extremities: A retrospective study of 352 patients.
Conclusions Extravascular findings are frequently encountered in magnetic resonance angiography performed for vascular indications. Clinically relevant findings are seen in a substantial part of patients and should prompt further diagnostic work-up. PMID: 28587578 [PubMed - as supplied by publisher]
Source: Vascular - January 1, 2017 Category: Surgery Authors: Sohns JM, Menke J, Bergau L, Weiss BG, Schmuck S, Weiberg D, Staab W, Derlin T, Dorenkamp M, Sohns C Tags: Vascular Source Type: research

Aggressive Phenotype of Intravascular Lymphoma Relative to Other Malignant Intra-abdominal Tumors Requiring Vascular Resection with Grafting
Intra-abdominal and retroperitoneal malignancies may require vascular surgical assistance to remove safely, with grafting of the aorta and/or vena cava to achieve negative margins. The current report reviews such major vascular-associated tumors at a single tertiary referral center.
Source: Annals of Vascular Surgery - March 13, 2018 Category: Surgery Authors: Andrea T. Obi, Gloria Kim, Dawn M. Coleman, Nicholas H. Osborne, John E. Rectenwald, Peter K. Henke, Jonathan L. Eliason Tags: Abstracts Accepted for Presentation During the 42nd Annual Meeting of the Vascular and Endovascular Surgery Society Source Type: research

BCL6B (B-Cell CLL/Lymphoma 6 Member B Protein) Contributes to Ocular Vascular Diseases via Notch Signal Silencing
CONCLUSIONS: These data indicate that BCL6B may be a novel therapeutic target for ocular vascular diseases characterized by ocular neovascularization and edema.PMID:37078291 | DOI:10.1161/ATVBAHA.123.318987
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 20, 2023 Category: Cardiology Authors: Miruto Tanaka Shinsuke Nakamura Tomohisa Sakaue Takumi Yamamoto Masashi Maekawa Anri Nishinaka Hiroto Yasuda Kaori Yunoki Yuji Sato Masaaki Sawa Kohichiro Yoshino Masamitsu Shimazawa Masahiko Hatano Takeshi Tokuhisa Shigeki Higashiyama Hideaki Hara Source Type: research

Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes
Pericytes and vascular smooth muscle cells (VSMCs), which are recruited to developing blood vessels by platelet-derived growth factor BB, support endothelial cell survival and vascular stability. Here, we report that imatinib, a tyrosine kinase inhibitor of platelet-derived growth factor receptor β (PDGFRβ), impaired growth of lymphoma in both human xenograft and murine allograft models. Lymphoma cells themselves neither expressed PDGFRβ nor were growth inhibited by imatinib. Tumor growth inhibition was associated with decreased microvascular density and increased vascular leakage. In vivo, imatinib induced ...
Source: Blood - June 27, 2013 Category: Hematology Authors: Ruan, J., Luo, M., Wang, C., Fan, L., Yang, S. N., Cardenas, M., Geng, H., Leonard, J. P., Melnick, A., Cerchietti, L., Hajjar, K. A. Tags: Vascular Biology, Lymphoid Neoplasia Source Type: research

Cytoprotective pathways in the vascular endothelium. Do they represent a viable therapeutic target?
Abstract The vascular endothelium is a critical interface, which separates the organs from the blood and its contents. The endothelium has a wide variety of functions and maintenance of endothelial homeostasis is a multi-dimensional active process, disruption of which has potentially deleterious consequences if not reversed. Vascular injury predisposes to endothelial apoptosis, dysfunction and development of atherosclerosis. Endothelial dysfunction is an end-point, a central feature of which is increased ROS generation, a reduction in endothelial nitric oxide synthase and increased nitric oxide consumption. A dysf...
Source: Vascular Pharmacology - August 8, 2016 Category: Drugs & Pharmacology Authors: Mason JC Tags: Vascul Pharmacol Source Type: research

Aggressive phenotype of intravascular lymphoma relative to other malignant intra-abdominal tumors requiring vascular reconstruction
Safe resection of intra-abdominal and retroperitoneal malignancies with a goal of negative margins may require vascular surgical assistance with grafting of the aorta and/or vena cava. The current report reviews malignancies associated with major vascular reconstructions at a single tertiary referral center.
Source: Annals of Vascular Surgery - September 26, 2018 Category: Surgery Authors: Andrea T. Obi, Gloria Y. Kim, Dawn M. Coleman, Nicholas H. Osborne, John E. Rectenwald, Katherine A. Gallagher, Peter K. Henke, Jonathan L. Eliason Source Type: research

Aggressive Phenotype of Intravascular Lymphoma Relative to Other Malignant Intraabdominal Tumors Requiring Vascular Reconstruction
Safe resection of intraabdominal and retroperitoneal malignancies with a goal of negative margins may require vascular surgical assistance with grafting of the aorta and/or vena cava. The current report reviews malignancies associated with major vascular reconstructions at a single tertiary referral center.
Source: Annals of Vascular Surgery - September 26, 2018 Category: Surgery Authors: Andrea T. Obi, Gloria Y. Kim, Dawn M. Coleman, Nicholas H. Osborne, John E. Rectenwald, Katherine A. Gallagher, Peter K. Henke, Jonathan L. Eliason Tags: Clinical Research Source Type: research

Immunohistochemical expression of p53, BCL-2, BAX and VEGFR1 proteins in nephroblastomas
CONCLUSIONS: The immunohistochemical expression of VEGFR1 substantiated a directly proportional association with the nephroblastoma risk group.INTRODUÇÃO: O nefroblastoma, ou tumor de Wilms, é a neoplasia renal mais frequente na infância. Embora o prognóstico seja favorável para a maioria dos pacientes, muitos evoluem para recidiva ou óbito. A caracterização de grupos de risco por meio de marcadores imuno-histoquímicos tem por objetivo adequar o tratamento ao grupo de risco e reduzir recidivas e óbitos. Entre os marcadores mais estudados estão p53, B-cell lymphoma 2 (BCL-2), BCL-2 associated protein X (BAX) e f...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 25, 2013 Category: Pathology Source Type: research

Pulmonary arterial hypertension in a patient with multiple myeloma during carfilzomib treatment: in search of better management.
CONCLUSION: The mechanism responsible for cardiac and vascular events during carfilzomib therapy is unclear. This case report highlights that it is important to define at baseline the appropriate screening of patients undergoing carfilzomib therapy with specific monitoring and symptom management and that future large prospective controlled studies are needed to define the correct monitoring strategy in refractory and relapsed multiple myeloma and the potential mechanism of vascular events. PMID: 33525991 [PubMed - as supplied by publisher]
Source: Tumori - February 4, 2021 Category: Cancer & Oncology Tags: Tumori Source Type: research